To take back the city, the Saints must dismantle the three gangs that make up the Syndicate:
: The Boss chooses to hunt down the Luchadores' leader. While successful, this leads to the destruction of a major city landmark and paints the Saints as public enemies, though they ultimately declare Steelport an independent city-state under their rule. Saints Row: A harmadik
: A Mexican wrestling-themed gang led by the massive Killbane, focused on narcotics and gambling. To take back the city, the Saints must
: Sophisticated European gangsters led by Loren himself, who control the city's nightlife and vice. : Sophisticated European gangsters led by Loren himself,
The Saints' celebrity status attracts the attention of , a legendary international criminal organization led by Philippe Loren. After a high-stakes bank heist in Stilwater goes wrong, the Saints' leaders—The Boss, Johnny Gat, and Shaundi—are captured. Loren demands they surrender two-thirds of their empire as "tribute". The Saints refuse, leading to a mid-air escape from Loren’s private jet. During the chaos, Johnny Gat is seemingly killed while holding off Syndicate forces to allow the others to escape.
: The Boss chooses to rescue Shaundi and the other Saints from a S.T.A.G. trap. This cement's the Saints' status as the beloved "kings" of Steelport.