Large breast tissue presents unique diagnostic and pathological challenges:

: Proper fit is essential for comfort and health. Specialists recommend accurate measurement to avoid common fitting mistakes, particularly for plus-size or DD+ needs.

: It can be difficult to distinguish between benign lesions like fibroadenomas (FA) and rare, more aggressive phyllodes tumors (PT) in large masses. PTs are more common in women over 35 and often require surgical excision.

Breast cancer development and progression: Risk factors, ... - PMC

For further academic research, you can explore detailed clinical reviews on Phyllodes Tumors or Mammary Gland Development .