Sensing: The C2D domain is identified as critical, as disruptions in this area alter synaptic sound encoding.
Lack of functional otoferlin or its C2 domain interaction prevents proper vesicle docking, leading to profound deafness. Summary Table: Otoferlin C2 Interactions Function/Location C2B-C2G Main interface for membrane binding C2D Crucial Ca 2+raised to the 2 plus power binding site; mutations affect sound encoding C2F-C2G Rearrange upon membrane binding to close structure Target Membrane Membrane where vesicles are docked tm,cc,jp
Binding Sites: High-resolution structures revealed that multiple Ca 2+raised to the 2 plus power Sensing: The C2D domain is identified as critical,
ions are bound per domain, with specific significance for the . It tethers vesicles to the plasma membrane, facilitating
It tethers vesicles to the plasma membrane, facilitating sound encoding.
Based on the 2025 research regarding the protein , which is crucial for hearing and synaptic transmission,
The protein utilizes C2 domains to bridge synaptic vesicles to the plasma membrane (plasma membrane being the "target membrane").