The_binding_of_isaac__afterbir... Apr 2026

: Consumes items for random stat ups or to combine active item effects.

: An in-game collection page that tracks encountered enemies, including kill counts and how many times they have killed the player. the_binding_of_isaac__afterbir...

: A feature that allows players to restart a new run with their current items after defeating the final boss, with difficulty increasing each lap. : Consumes items for random stat ups or

: Introduces 20 new standard enemies and 6 new bosses, including variant champion forms. the_binding_of_isaac__afterbir...

: Five new challenges, including "Backasswards" (where you start at the final boss and work your way back to the beginning) and "April's Fool" . Game Adjustments & UI