Holmes replaces his classic violin with a hand-sized keytar and uses the catchphrase "eyes and brain" to explain his reasoning.

Each episode is loosely inspired by one of Sir Arthur Conan Doyle’s original stories—such as The Hound of the Baskervilles or The Adventure of the Empty House —but recontextualized with sci-fi elements like data-sucking "vampires" and cyber-crimes.

In the year 2103, a criminal mastermind who appears to be Moriarty resurfaces. Inspector , a descendant of the original Inspector Lestrade, discovers that the original Holmes’ body has been preserved in a glass coffin. Using advanced cellular rejuvenation, Holmes is revived to his physical prime (approximately 25–30 years old) to stop the Moriarty clone. A Reimagined Team

The show features a unique blend of 2D character animation and 3D CGI for vehicles (hovercars) and cityscapes.

Since the original Dr. Watson is long gone, Lestrade uses a robot assistant. After reading Watson's journals, the droid emulates his personality and wears a prosthetic mask to resemble Holmes' old friend.

A tough, competent officer at New Scotland Yard who often clashes with Holmes’ unorthodox, old-fashioned methods.