Julian Baker approaches Brooke with a proposal for her to design costumes for his film, leading to a tense professional and personal dynamic.
While the term "Autopsy" appears in this title, it should not be confused with the documentary series Autopsy: The Last Hours of... , which also has a Season 6 but focuses on forensic investigations of celebrity deaths. You Have to Be Joking (Autopsy of the Devil's Brain)
Peyton struggles to keep Mia focused on her follow-up album while managing her record label.
Nathan receives an invitation for a professional basketball tryout, a significant step in his attempted comeback after his injury.
Like many One Tree Hill episodes, the title is a reference to a song; "You Have to Be Joking (Autopsy of the Devil's Brain)" is a track by the band The Flaming Lips .
Lucas travels to Hollywood to meet with a film director regarding his movie project.
The episode serves as the mid-season finale for Season 6.