[s5e22] What A Difference A Day Makes Today

: Creator Shonda Rhimes noted that Denny's appearance in this episode was meant to represent "Death," which is why he wore black and spoke sparingly compared to previous appearances.

: Rhimes described the episode as the moment Meredith evolved from a "dark and twisty" girl into an "extraordinary" woman capable of choosing happiness. [S5E22] What a Difference a Day Makes

: George O'Malley faces an emotional crisis when almost all the students from the accident die under his care, leaving him devastated until Owen Hunt helps him see the lives he did save. : Creator Shonda Rhimes noted that Denny's appearance

: Jeffrey Dean Morgan makes a final appearance as Denny Duquette, appearing as a hallucination to Izzie that Derek and Bailey eventually realize is a symptom of her worsening condition. Behind the Scenes Facts : Jeffrey Dean Morgan makes a final appearance

While the wedding takes center stage, the hospital remains in chaos due to a tragic car crash involving college students on their way to graduation.