For more detailed production history and award information, you can visit the House's Head Wikipedia page and the Wilson's Heart Wikipedia page .
: House is motivated by an unfamiliar sense of guilt. He ponders the unfairness of a "misanthropic drug addict" surviving while a promising young physician dies.
In the second part, "Wilson's Heart," the team discovers Amber is suffering from multisystem organ failure. [S4E16] House's Head (Part 2)
: House deduces that Amber was taking amantadine for the flu. The crash caused acute kidney failure, preventing her body from processing the drug and resulting in lethal amantadine poisoning.
: The recovered memory reveals that House, too drunk to drive, called Wilson for a ride; Amber arrived instead. They were on the bus together when the accident occurred. The Medical and Moral Failure For more detailed production history and award information,
: The finale fundamentally alters the series' core relationship. Wilson is left alone, finding a final note from Amber, while House awakens from a coma to face the wreckage of his friendship.
: Because amantadine binds to proteins, it cannot be cleared via dialysis. House must inform a devastated Wilson that there is no cure. Major Themes In the second part, "Wilson's Heart," the team
: The episode concludes with Thirteen testing positive for Huntington’s disease, echoing the theme that life is often "unfair" and beyond a doctor's control.