Brian returns from the school completely submissive and "broken," behaving like a typical, boring dog. Peter quickly realizes he misses his feisty, intellectual friend and must find a way to snap him back to his old self.

The title refers to bite marks found on Renata’s daughter, Amabella, which reignites the school-wide hunt for a bully and further isolates Jane’s son, Ziggy. Cultural Origin: The 1985 Film "Family Guy" Once Bitten (TV Episode 2015) - IMDb

Celeste (Nicole Kidman) has a solo therapy session with Dr. Reisman. In a masterfully acted scene, the therapist pushes past Celeste’s justifications, finally getting her to admit the danger she is in with her husband, Perry.

After Brian gets sick from excessive drinking, Peter attempts to give him a suppository, leading a frustrated Brian to bite him. This makes Peter terrified of his own dog, eventually leading Lois to send Brian to a military-style obedience school.