In polite company, the goal is often to be discreet. Using "softer" language is generally preferred.
Most classrooms require a specific protocol. "May I please use the restroom?" is the standard. Many modern classrooms also use a non-verbal hand signal (like holding up a crossed index and middle finger) to avoid interrupting the lesson. 3. International Travel (The Essentials) Requests to Use the Bathroom and Toilet /Ask to...
Use consistent words like "Potty" or "Bathroom" so they don't get confused. In polite company, the goal is often to be discreet
"Excuse me, where is the restroom?"
"Could you tell me where the bathroom is?" In polite company
In a meeting, it is often better to wait for a break. If you must go, a quick, "Excuse me, I'll be back in a moment," is usually enough.