Nfl San Francisco 49ers Vs Arizona Cardinals [ TOP — Edition ]

The dynamic of this rivalry shifted significantly during the 2024 season, which saw Arizona complete a rare sweep of San Francisco.

The 49ers regained momentum in the 2025 campaign, winning both matchups:

The and San Francisco 49ers have a storied NFC West rivalry, with the 49ers currently leading the all-time series 38–31 . Recent Series Recap (2024–2025 Seasons) NFL San Francisco 49ers vs Arizona Cardinals

According to the 49ers–Cardinals rivalry history , the series is defined by long streaks of dominance. San Francisco 49ers Arizona Cardinals 38 Wins Longest Win Streak 5 Games (Three times) 8 Games (2015–2018) Largest Victory 50–14 (2003) 47–7 (2015) Playoff Meetings Key Rivalry Trends

The Cardinals overcame a halftime deficit to stun the 49ers 24–23 at Levi's Stadium. This game set a record for the hottest regular-season kickoff at the stadium at The dynamic of this rivalry shifted significantly during

A gritty 16–15 defensive battle that went to San Francisco.

The 49ers "crushed" the Cardinals 41–22 . Brock Purdy threw three touchdowns, and Christian McCaffrey found the end zone three times. Historical Series Statistics San Francisco 49ers Arizona Cardinals 38 Wins Longest

Arizona handed the 49ers a humiliating 47–24 loss, which sealed San Francisco's "disastrous" 6–11 season and secured them the No. 11 pick in the draft. Kyler Murray threw four touchdowns in the blowout.