While Nicolas Cage does not appear in the first season, the series maintains continuity with the movies through several key links:

: One of the main characters, Liam, is revealed to be the grandson of Agent Sadusky, providing a bridge between the old and new guards.

The story kicks off when Jess meets a mysterious stranger who gives her a clue to a centuries-old treasure possibly linked to her deceased father. Alongside her tech-savvy friends, Jess embarks on a Pan-American adventure to find lost Aztec, Incan, and Mayan artifacts before they fall into the hands of Billie Pearce, a ruthless black-market antiquities dealer.