As the bus journey progresses, the passengers begin to experience strange and unexplained events. They soon discover that the bus is equipped with a mysterious device that allows the driver to manipulate the passengers' memories. The device, known as the "MIRD-125," can erase, alter, and even implant memories.

The story takes place on a bus traveling from Tokyo to a rural town in Japan. The bus, operated by a company called "Bakobako Bus," is on its way to a small town for a Thanksgiving-themed event. On board are a diverse group of passengers, including a young couple, a family with children, and a few elderly individuals.

"MIRD-125: Thanksgiving Bakobako Bus" received positive reviews from audiences and critics alike. The series was praised for its unique storyline, engaging characters, and thought-provoking themes. The show's average viewership rating was around 6%, which is a respectable figure for a Japanese drama.

The drama was produced by TV Asahi and directed by Takashi Nagasaki, who is known for his work on several Japanese dramas and films. The screenplay was written by Kenta Fukasaku, who is the son of the renowned filmmaker Kinji Fukasaku.

The passengers soon find themselves trapped in a cat-and-mouse game, as they try to uncover the truth behind the device and the bus driver's intentions. Along the way, they must confront their own dark pasts and relationships with each other.