The original audio comes from a titled " Azonto Ghost ." In one scene, the character played by Kwadwo Nkansah (popularly known as Lil Win) reacts with an extremely high-pitched, melodic "Oh my God!" upon seeing a ghost. Evolution into a Meme
More recently, the audio experienced a resurgence through the "Momoi Girl" or "Memoi Girl" trend. This often involves anime-style avatars (specifically Momoi from Blue Archive ) or AI-generated voices reacting to famous celebrities or characters with the signature "Oh my God, it's...!" catchphrase. memeoh_my_god
Watch how the meme has evolved into a popular editing style on social media: The original audio comes from a titled " Azonto Ghost