Season 5 of Malcolm in the Middle , which originally aired from November 2003 to May 2004, is defined by the family's transition as the boys grow into their teenage years and adjust to the newest addition, baby Jamie.
: Directed by Bryan Cranston , this episode features Malcolm and Stevie needing the "unintelligent" Reese to help solve a complex scientific enzyme problem. Malcolm in The Middle - Season 5
: Malcolm continues to assert himself in high school, dealing with censorship in the school newsletter and navigating complex social circles, such as "dating" a girl's entire intellectual family. Season 5 of Malcolm in the Middle ,
: Following his birth at the end of Season 4, Jamie becomes a central figure, leading to new dynamics like "baby gambling" among local fathers and Lois struggling to maintain her usual level of control. : Following his birth at the end of
: A two-part finale where Reese runs away to enlist after a heartbreak, and Hal faces potential jail time for his company’s legal troubles. Main Cast & Guest Stars Frankie Muniz Bryan Cranston Jane Kaczmarek Justin Berfield Erik Per Sullivan Christopher Masterson Notable Guest Cloris Leachman as Grandma Ida Notable Guest David Cassidy as Boone Vincent