Lady Macbeth’s quest for power begins with a literal and symbolic rejection of her womanhood. In Act 1, Scene 5, she famously implores spirits to "unsex me here" and replace her "milk for gall".
: She asks for her blood to be thickened to block out "compunctious visitings of nature," effectively attempting to surgically remove her conscience to facilitate murder. Manipulation and Agency Lady Macbeth
: In a society where women were expected to be submissive and nurturing, she demands "direst cruelty". Lady Macbeth’s quest for power begins with a