G9048.mp4 -

: Observations of "leader cells" responding to GLI2 inhibition.

: Injured epithelial cells release Sonic Hedgehog (SHH) ligands. g9048.mp4

: Visual evidence of cell mobility and invasiveness. : Observations of "leader cells" responding to GLI2

: This signaling activates fibroblasts, which increase tissue stiffness by producing collagen. g9048.mp4

: The resulting stiffened tissue triggers non-canonical activation of the transcription factor GLI2 in epithelial cells.

The research, published in journals such as and archived on PMC , explores how tissue stiffness and biochemical signaling work together to drive cancer growth. Key Research Findings