He discovers that the universe is made of pixels. This "Theory of Everything" initially depresses him because it leaves no more scientific mysteries to solve.
The crew tries to negotiate, but their attempts at "dance-talk" are misinterpreted as hostilities. Futurama - Season 6Eps26
Fry uses a doomsday device to break the comet, creating an entirely new color. However, because the animation is black and white, the audience (and characters) see only shades of gray. Segment 2: "Future Challenge 3000" (8-Bit Video Game Style) He discovers that the universe is made of pixels