Indicators like biomarkers that predict a clinical benefit, even if they aren't the benefit themselves. 4. The Ethics of Equipoise
Neither the patient nor the researcher knows.As a trialist, your job is to maintain this "seal" throughout the study. Once the blind is broken, the statistical weight of your findings drops significantly. 3. Choosing the Right Endpoints Fundamental Concepts for New Clinical Trialists
This is the moral compass of clinical trials. is the genuine uncertainty within the medical community about which treatment is better. If we already know for a fact that Treatment A is superior to Treatment B, it is unethical to start a trial. We only experiment when there is a true "honest doubt" to resolve. Indicators like biomarkers that predict a clinical benefit,
What does "success" look like? You must define this before the first patient is enrolled. Once the blind is broken, the statistical weight