We found that changes in the cellular levels of AKT1 lead to changes in the levels of a set of differentially expressed genes and, Akt isoforms in the immune system - Frontiers
Multi-Isoform AKT Signaling: A Systems-Level Analysis of Cellular Homeostasis and Oncogenesis File: AKT_collection_compressed_2022-11-20.zip ...
: The primary regulator of insulin-dependent glucose uptake in muscle and adipose tissue. We found that changes in the cellular levels
AKT (Protein Kinase B) is a critical serine-threonine kinase existing in three isoforms (AKT1, AKT2, AKT3) that integrates signals from the PI3K pathway to regulate metabolism, survival, and proliferation. This paper analyzes the distinct and overlapping roles of these isoforms using transcriptomic landscapes and multi-omic profiling. We demonstrate that while AKT1 primarily drives somatic growth, AKT2 is essential for glucose metabolism, and AKT3 influences neuronal development. Furthermore, we explore how aberrant activation via somatic mutations, such as AKT1 (E17K), contributes to tumorigenesis in breast and colorectal cancers. 1. Introduction We demonstrate that while AKT1 primarily drives somatic
Research indicates that AKT isoforms are not functionally redundant:
: Predominantly expressed in the brain, where it regulates organ size and neurodevelopment. 3. Pathological Dysregulation 3.1 Cancer
: Central to cell survival and general growth; its depletion leads to significant transcriptomic shifts in breast cancer cells.