Download: 91566

To obtain the full technical report or the PDF of this article: Visit the official eLife article page.

Download links * Insight. * Structural Biology and Molecular Biophysics. * CaMKII. * actinin. * long-term potentiation. * synapse.

Supplemental information, including data sets and molecular models, is also available for download on the same page. Synapses: Changing the size of dendritic spines - eLife Download 91566

Dendritic spines are tiny protrusions on neurons that receive input from other cells. Their size is a direct physical indicator of —larger spines generally correlate with stronger connections. This report examines how these structures change size (structural plasticity), which is a fundamental process underlying learning and memory. 2. Key Findings

Understanding how dendritic spines change size helps researchers decipher the brain's "wiring" and how it stores information. Disruptions in this structural plasticity are often linked to various neurological and cognitive disorders. To obtain the full technical report or the

Mechanisms of Synaptic Strength and Spine Size Regulation Reference: eLife 2023;12:e91566 1. Overview

The research highlights how the spine's physical volume adapts in response to neural activity, specifically focusing on the biochemical signaling that triggers these expansions. 3. Significance * CaMKII

Changes in spine size are closely linked to LTP, a process that strengthens synapses over time.