Law: Distribution

Solubility is temperature-dependent; therefore, KDcap K sub cap D only remains constant if the temperature is stable.

are the equilibrium concentrations of the solute in Solvent 1 and Solvent 2. KDcap K sub cap D is the Distribution Coefficient (or Partition Coefficient). Necessary Conditions and Limitations distribution law

In pharmacology, the partition coefficient (often expressed as Log P) helps scientists predict how easily a drug can cross cell membranes, which are primarily composed of lipids. Solubility is temperature-dependent