Biologics, A History Of Agents Made From Living... -

A fascinating story of the discovery & development of ... - PMC

: The first monoclonal antibody therapy, Muromonab-CD3, was approved, introducing a new level of precision by targeting specific proteins in the immune system.

: In St. Louis, 13 children died of tetanus after receiving diphtheria antitoxin derived from a retired milk wagon horse named Jim, who had contracted tetanus. Biologics, A History of Agents Made From Living...

Early production lacked oversight, leading to tragedies that spurred federal regulation of biological products.

: Human insulin (Humulin) became the first FDA-approved drug produced via recombinant DNA technology, offering a safer and more consistent alternative to animal-derived insulin. A fascinating story of the discovery & development of

: Scientists like Emil von Behring and Shibasaburo Kitasato discovered that the blood serum of immunized animals contained "antitoxins" (now known as antibodies). In 1891, the first child was treated with diphtheria antitoxin, a breakthrough that significantly reduced mortality from the disease. A Turning Point: Regulation and Safety (1901 – 1902)

: Edward Jenner pioneered the first vaccine using material from cowpox sores to confer immunity against smallpox, laying the groundwork for modern immunology. Louis, 13 children died of tetanus after receiving

The foundation of biologics began with early immunology and the use of natural substances to prevent or treat infectious diseases.