Elevated AFP levels may indicate neural tube defects (such as spina bifida or anencephaly), abdominal wall defects, twin pregnancy, or an incorrectly estimated gestational age.
1. Alpha-Fetoprotein (AFP) in Pregnancy (Prenatal Screening) alpha fetoprotein
It is a screening test, not a diagnostic one. A positive screen does not mean a definite abnormality; further diagnostics, such as an ultrasound or amniocentesis, are usually required. 2. Alpha-Fetoprotein (AFP) as a Tumor Marker Alpha-Fetoprotein (AFP) Test: MedlinePlus Medical Test Elevated AFP levels may indicate neural tube defects
Lower than normal levels may indicate Down syndrome (trisomy 21) or Edwards syndrome (trisomy 18). A positive screen does not mean a definite
The maternal serum AFP (MSAFP) test is a blood test performed during the second trimester (typically between 15 and 20 weeks) to assess the risk of fetal abnormalities.
Alpha-fetoprotein (AFP) is a protein produced primarily by the liver and yolk sac of a developing fetus during pregnancy. While levels are high in fetuses and decrease significantly by age 1, AFP testing is used in two distinct medical contexts: prenatal screening and tumor marker monitoring.