A Hard Day's Nightgrey's Anatomy : Season 1 Epi... -

"," the series premiere of Grey's Anatomy , aired on March 27, 2005, and introduced viewers to the high-stakes world of surgical interns at Seattle Grace Hospital. Episode Overview

The episode follows on her first day as an intern, a journey complicated by a one-night stand with a man she soon discovers is her boss, attending neurosurgeon Derek Shepherd . Under the grueling supervision of resident Miranda Bailey (nicknamed "The Nazi"), Meredith and her fellow interns— Cristina Yang , George O'Malley , Izzie Stevens , and Alex Karev —struggle to survive a 48-hour shift. Key Plot Points A Hard Day's NightGrey's Anatomy : Season 1 Epi...

George is chosen by Dr. Burke to perform the first appendectomy of the year, but he freezes under pressure, earning the nickname "007" (licensed to kill). "," the series premiere of Grey's Anatomy ,

Sandra Oh originally auditioned for the role of Miranda Bailey before being cast as Cristina Yang . Key Plot Points George is chosen by Dr

The pilot set the tone for the series' signature blend of intense medical drama and complex romantic entanglements, eventually becoming the longest-running scripted primetime medical drama in TV history.

Meredith is mortified to find Derek at the hospital and attempts to keep their encounter a secret.